This article explores the contents and differential traits of (a) trans* epistemology, as a way to contribute to a dialogue fundamental both from a scholarly perspective and from the point of view of trans* advocacy. The first section offers a brief introduction to trans* studies, highlighting some key aspects in relation to an epistemology rooted in philosophical reflection. The second section presents some of the main critiques trans* scholars have advanced in relation to the processes of knowledge production and its products. The section then moves on to some of the field's main constructive proposals in this respect. The third section builds on the concept of “cis” and “cissexism” to offer considerations on the nuanced relationship between critique and positive contributions, and on the resistance on the part of cis people to being named as such. Finally, the work offers some closing remarks in relation to the specificity and challenges of (a) trans* epistemology.