Coast Salish people, particularly the Stó:lõ of the lower Fraser Valley, have lost much of their language, histories, and teachings as a result of colonization. One such important identity that has been forgotten or erased is the two-spirited role. The author wishes to revitalize the cultural roles of transgendered/two-spirit people within the Coast Salish territory and ways in which they historically contributed to their societies prior to colonization. Traditionally, the Stó:lõ are matriarchal and matrilineal, and only grandmothers can create any new laws for their descendants. Thus given the vital role played by the author's grandmother in her process, this essay is a long-overdue proposal to all living grandmothers not only to stand by and accept their two-spirited grandchildren but to call for a celebration of their coming out. This visionary work serves to inspire future generations of Stó:lõ to fully embrace all members of their community, especially two-spirits. The first Sts'iyóye Smestíyexw Slhá:li, or Twin-Spirited Woman, as this essay is about, offers an example to this sacred work.