The California ballot initiative for partial marijuana legalization (Proposition 19) may have been defeated for the moment, but nevertheless more than four million voters said “yes” to it. Between the recent reduction in California’s penalties for use—now reduced to a fine for possession of under an ounce of marijuana—and the burgeoning medical marijuana industry, clearly the times are a-changin’. There are many hundreds of thousands of certified medical marijuana users in California, and twelve other states now have some reduction in marijuana criminalization as well. With scientific research into the clinical effects of psychedelics also burgeoning and a growing number of papers indicating benefit for various psychiatric conditions (post-traumatic stress disorder, depression, terminal illnesses, and drug addiction), thereby bolstering historic claims for clinical utility, and with the horrific costs of failed prohibition more and more obvious to the public, decriminalization—if not legalization—has become...

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