This article explores the intersection between migrant detention and HIV/AIDS from the 1980s to the present. “AIDS Knows No Borders” centers histories of exclusion, detention, and deportation. The first part discusses immigration policy that made AIDS screening mandatory as part of the asylum process and the activism that resulted in protest of these measures. AIDS Coalition to Unleash Power/Los Angeles (ACT UP/LA), a grassroots direct-action organization, opposed this legislation throughout the 1980s and 1990s. Activists highlighted the global nature of AIDS; challenged misinformation; conducted guerilla theater, phone zaps, and die-ins; and held demonstrations against the INS, the use of immigration detention, and their treatment of migrants with HIV/AIDS. The article then moves to discuss more contemporary testimonies from HIV/AIDS-positive detention migrants.