Employing an anticolonial and anticapitalist approach to HIV/AIDS, the activists of the Latina/o Caucus of ACT UP/NY pushed beyond a biomedical framework of “drugs into bodies” that tended to dominate the larger organization. As US queer racialized/colonial subjects, Latinx AIDS activists enacted a queer and feminist decolonial activism that looked past the continental United States to the global South. In Puerto Rico, Latinx AIDS activists helped establish the first chapter of ACT UP in a Spanish-speaking country. Together, the Latina/o Caucus and ACT UP/Puerto Rico spearheaded a campaign against the colonial policies of the United States, the corporate greed of island-based pharmaceutical firms, and the heteropatriarchal investments of church and commonwealth officials—conditions that exacerbated the disproportionate rates of HIV/AIDS among Puerto Rican island and diasporic communities. Through these efforts, Latinx AIDS activists transformed the domestic and global fight against AIDS into a queer, feminist, and decolonial endeavor.