Through examination of four examples from contemporary metabolic sciences, this article characterizes the rise of a postindustrial metabolism. Concerned with regulation, timing, and information, this emergent metabolism is analyzed as a shift away from the factory or motor model of classic metabolism, in which food was fuel, providing energy and building blocks to the body. Accordingly, metabolic disorders—treatments for which are the explicit aim of much of this research—are increasingly explained and intervened in as regulatory crises, asynchronies, or instances of misinformation. Close examination of the explanatory frameworks and experimental design of the contemporary metabolic sciences answers, with some specificity, the question of the knowledge effects of obesity and diabetes research, or fat knowledge.

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