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Genome-wide genotype
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Journal Article
Demography (2015) 52 (5): 1651–1670.
Published: 29 August 2015
... by (1) heritability or the proportion of variance in BMI explained by genome-wide genotype data, and (2) the random effects or the best linear unbiased predictors (BLUPs) of genome-wide association studies (GWAS) data on BMI. Data were used from the Framingham Heart Study (FHS) in the United States...
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in The Genome-Wide Influence on Human BMI Depends on Physical Activity, Life Course, and Historical Period
> Demography
Published: 29 August 2015
Fig. 2 Estimated heritability or the proportion of the variance in BMI explained by genome-wide genotype data by age and historical period in FHS
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Journal Article
Demography (2014) 51 (1): 119–139.
Published: 27 November 2013
... ). Recent declines in the costs of genome-wide genotyping in conjunction with an increasing number of population-based studies with genome-wide data make a genome-wide gene-by-environment interaction (GWGEI) approach possible (Cornelis et al. 2012 ; Mukherjee et al. 2012 ; Thomas et al. 2012...
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Journal Article
Demography (2022) 59 (3): 1045–1070.
Published: 01 June 2022
.... , . . . Visscher P. M. ( 2012 ). FTO genotype is associated with phenotypic variability of body mass index . Nature , 490 , 267 – 272 . Young A. I. , Wauthier F. L. , & Donnelly P. ( 2018 ). Identifying loci affecting trait variability and detecting interactions in genome-wide...
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Includes: Supplementary data
Journal Article
Demography (2023) 60 (5): 1523–1547.
Published: 01 October 2023
.... The PGI provides a summary measure of the known genetic propensity for a trait. The index is generated by multiplying the association strength of a given copy of a single-nucleotide polymorphism (SNP, the most fundamental unit of genetic variation), obtained from an independent genome-wide association...
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Includes: Supplementary data
Journal Article
Demography (2018) 55 (4): 1245–1267.
Published: 05 July 2018
... this empirical pattern is genetic confounding, wherein gene-environment correlation (rGE) causes a spurious relationship between father absence and reproductive timing. We test this hypothesis by constructing polygenic scores for age at menarche and first birth using recently available genome-wide association...
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Journal Article
Demography (2014) 51 (1): 141–172.
Published: 10 September 2013
... than .001. The genetic analysis was based on the 162 of 186 AIMs that were successfully genotyped. In Add Health, genomic DNA was isolated from buccal cells at the Institute of Behavior Genetics at the University of Colorado, Boulder. The average yield of DNA was 58 ± 1 μg. We designed...
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Journal Article
Demography (2006) 43 (4): 747–769.
Published: 01 November 2006
... like to acknowledge the key collaborators of Add Health Andy Smolen and John Hewitt at the Institute for Behavioral Genetics, the University of Colorado who isolated genomic DNA and carried out genotyping (httpwww.cpc.unc.edu/projects/addhealth We gratefully acknowledge support from NIH, P01-HD31921...
Journal Article
Demography (2021) 58 (4): 1575–1602.
Published: 01 August 2021
... role of genetic factors in explaining variation in family transitions and events across the life course. We estimate the genetic contribution to sequence complexity and a wide range of family demographic behaviors using genomic relatedness–based, restricted maximum likelihood models with data from...
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Includes: Supplementary data
Journal Article
Demography (1990) 27 (2): 185–206.
Published: 01 May 1990
... genome and increases the frequency of recessive phenotypes. Special nonrandom samples may also contain very different genotype distributions, which can be useful for understanding the genetic basis of traits of interest. Even with random mating, families are sampling units with highly correlated rr...
Journal Article
Demography (2023) 60 (6): 1631–1648.
Published: 01 December 2023
... to conduct a genome-wide association study (GWAS) for migration distance. We then calculated genetic correlations to compare GWAS results for migration with those for other characteristics. Given that individual genetics are determined at conception, these analyses allow a unique exploration...
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Includes: Supplementary data
Journal Article
Demography (2010) 47 (Suppl 1): S111–S130.
Published: 01 March 2010
... to outcomes of interest. The HRS is pursuing a different path to enable genome-wide association stud- ies. With stimulus funding from the NIA, the 13,000 HRS DNA samples will be genotyped using the Illumina HumanOmni1-Quad BeadChip, which covers a million single nucleotide polymorphisms (SNPs). Using...
Journal Article
Demography (1997) 34 (1): 17–30.
Published: 01 February 1997
... , 127 – 35 . Cohen J. ( 1996 ). New Role for HIV: A Vehicle for Moving Genes Into Cells . Science , 272 , 195 – 195 . Collins F. , & Galas D. ( 1993 ). A New Five-Year Plan for the U.S. Human Genome Project . Science , 262 , 43 – 46 . Comfort A. ( 1979...
Journal Article
Demography (2024) 61 (2): 363–392.
Published: 01 April 2024
... that is needed to create a genetic summary measure (called a polygenic index) is the existence of published summary statistics from genome-wide association studies (GWAS) in the domain of interest. 2 Using data from the UK Biobank, a large-scale biobank study with approximately 500,000 genotyped...
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Includes: Supplementary data
Journal Article
Demography (2017) 54 (2): 721–743.
Published: 09 March 2017
.... , Nelson , M. L. , Fisher , C. , Gunzerath , L. , Brody , C. L. , Hu , S. , . . . Hamer , D. H. ( 1999 ). A genetic association for cigarette smoking behavior . Health Psychology , 18 , 7 – 13 . Smith , J. G. , & Newton-Cheh , C. ( 2015 ). Genome-wide...
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Journal Article
Demography (2010) 47 (2): 327–343.
Published: 01 May 2010
...¿ ed with genomic association studies insofar as they are independently arising mutations that are likely to involve a wide variety of loci on the genome. Social Demographic Change and Autism 329 birth, breech birth, and low APGAR score at ¿ ve minutes to parental characteristics, such as socioeconomic...
Journal Article
Demography (2017) 54 (1): 71–91.
Published: 09 January 2017
... de Démographie , 29 , 1 – 38 . 10.1007/s10680-012-9277-y . Barban , N. , Jansen , R. , Vlaming , R. , Vaez , A. , Mandemakers , J. J. , Tropf , F. C. , & Mills , M. C. ( 2016 ). Genome-wide analysis identifies 12 loci influencing human reproductive behavior...
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Journal Article
Demography (2024) 61 (5): 1637–1666.
Published: 01 October 2024
.... J. , Nivard M. G. , Morris T. T. , Hansen A. F. , Rasheed H. , Cho Y. , . . . Davies N. M. ( 2022 ). Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects . Nature: Genetics , 54 , 581 – 592 . Hsin...
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Includes: Supplementary data
Journal Article
Demography (1998) 35 (4): 391–412.
Published: 01 November 1998
... . Population and Development Review , 7 , 229 – 54 . 10.2307/1972622 Curtsinger , J.W. , Fukui , H.H. , Townsend , D.R. , & Vaupel , J.W. ( 1992 ). Demography of Genotypes: Failure of the Limited LifeSpan Paradigm in Drosophila melongaster . Science , 258 , 461 – 63...
Journal Article
Demography (1997) 34 (1): 49–66.
Published: 01 February 1997
.... ( 1992 ). “Demography of Genotypes: Failure of the Limited LifeSpan Paradigm . Drosophila melanogaster.” Science , 258 , 461 – 63 . Dasgupta P. ( 1993 ). Inquiry Into Well-Being and Destitution . Oxford : Clarendon . Dublin L.I. , & Lotka A.J. ( 1936 ). Length of Life...
