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Gene-environment interaction for obesity
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Journal Article
Demography (2014) 51 (1): 119–139.
Published: 27 November 2013
... into their analyses. 23 10 2013 27 11 2013 © Population Association of America 2013 2013 Gene-environment interactions Genome-wide GWAS BMI Framingham Heart Study Many health behaviors of interest to demographers—including smoking, alcohol consumption, and obesity—are strongly...
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Journal Article
Demography (2015) 52 (5): 1651–1670.
Published: 29 August 2015
... origins of obesity . Obesity Reviews , 9 , 165 – 180 . 10.1111/j.1467-789X.2007.00392.x . Boardman , J. D. , Domingue , B. W. , Blalock , C. L. , Haberstick , B. C. , Harris , K. M. , & McQueen , M. B. ( 2014 ). Is the gene-environment interaction paradigm relevant...
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Journal Article
Demography (2022) 59 (3): 1045–1070.
Published: 01 June 2022
.... They used a genome-wide gene-by-environment interaction approach, which regresses the level of an outcome (in their case, BMI) on each SNP’s interaction with an environmental moderator (in their study, education). They noted the approach’s promise for capturing GxE but also its challenges with statistical...
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Includes: Supplementary data
Journal Article
Demography (2010) 47 (1): 1–22.
Published: 01 February 2010
... to test for sexually transmitted infections (STIs) and HIV. To strengthen our genetic design, we collected buccal cell DNA for molecular analysis of genetic and gene-environment interaction effects in health and health behavior. At Wave IV, we focused on the major health risks of the cohort at this time...
Journal Article
Demography (2001) 38 (4): 573–576.
Published: 01 November 2001
... fetal genes could interact with environmental effects; thus we began by testing for main effects. Another reason is that interactions between genotype and environment seem difficult to detect (McCall 1991; Wahlsten 1990): among the possible explanations are methodological limitations that apply to our...
Journal Article
Demography (2010) 47 (Suppl 1): S111–S130.
Published: 01 March 2010
..., personality traits result from the interplay of genetic variations with environmental inÀ uences (Loehlin 1992; National Research Council 2006). The gene-environment interaction approach assumes that environmental factors, such as life events, inÀ uence personality, and genes affect individual susceptibility...
Journal Article
Demography (2018) 55 (2): 387–402.
Published: 06 March 2018
... apparent in young adults (Belsky et al. 2015 ), the variance in biological age may increase with chronological age. Assuming that negative effects of environment and genes accumulate over the lifetime (Phoenix and de Grey 2007 ), biological age estimates may not differentiate individuals to the same...
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Journal Article
Demography (2010) 47 (1): 79–96.
Published: 01 February 2010
... in Newly Westernized Populations: Is It Due to Thrifty Genes or to Genetically Unknown Foods? . Journal of the Royal Society of Medicine , 91 , 622 – 25 . Baschetti R. ( 1999 ). Genetically Unknown Foods or Thrifty Genes? . American Journal of Clinical Nutrition , 70 , 420 – 21...
Journal Article
Demography (2014) 51 (5): 1573–1596.
Published: 09 September 2014
..., and neighborhoods) but only 50 % of their genes. We can therefore exploit the so-called genetic lottery—or, more formally, Mendellian randomization—in which inheritance of a particular gene is randomly distributed between children in a given family (Lawlor et al. 2008 ). Then, most of the variation in body size...
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Journal Article
Demography (2018) 55 (1): 295–318.
Published: 18 December 2017
... of education and body mass index . Demography , 51 , 119 – 139 . 10.1007/s13524-013-0259-4 . Bouchard , C. ( 2008 ). Gene–environment interactions in the etiology of obesity: Defining the fundamentals . Obesity , 16 ( S3 ), S5 – S10 . 10.1038/oby.2008.528 . Campbell , C. D...
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Journal Article
Demography (2024) 61 (2): 363–392.
Published: 01 April 2024
..., and economics used genetic data to investigate gene–environment interactions ( Boardman et al. 2014 ; Herd et al. 2019 ; Johnson et al. 2022 ; Liu 2018 ; Liu and Guo 2015 ) or to account for genetic confounding ( Fletcher et al. 2021 ; Gaydosh et al. 2018 ). The goal of these studies is to evaluate a role...
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Journal Article
Demography (2012) 49 (2): 525–552.
Published: 28 February 2012
...: Update . The Stata Journal , 5 , 1 – 14 . Rutter M. , & Silberg J. ( 2002 ). Gene-environment interplay in relation to emotional and behavioral disturbance . Annual Review of Psychology , 53 , 463 – 490 . 10.1146/annurev.psych.53.100901.135223 Shea A. K...
Journal Article
Demography (2024) 61 (4): 1023–1041.
Published: 01 August 2024
... research by identifying a biological pathway underlying this process. We focus on lifetime cigarette smoking as a model exposure. DNAm is an epigenetic mechanism—a process that affects gene expression in response to environmental factors without altering the underlying genetic code—that has been...
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Journal Article
Demography (2023) 60 (6): 1747–1766.
Published: 01 December 2023
...” that trigger predictive adaptive responses (PAR) in the form of epigenetic modifications that affect a later phenotype, which is, therefore, established by early-life gene–environment interactions ( Godfrey et al. 2007 ). When the PAR is “mismatched” with the individual's actual later mature environment...
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Journal Article
Demography (2018) 55 (4): 1245–1267.
Published: 05 July 2018
... unobserved heterogeneity, allowing for more precise estimation of environmental effects, as well as investigations of interactions between genes and environments. We provide here an example of an approach proposed by Manski ( 2011 ) and others (Belsky and Israel 2014 ; Benjamin et al. 2012 ) that applies...
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Journal Article
Demography (1990) 27 (2): 185–206.
Published: 01 May 1990
... additively, producing the following phenotype (P) distribution: P=C+PG+E fl.p = L Pr(g)fl.g g a~ = ai + a~ + a;. (5) This model is shown in Figure l(bottom). Terms for nonadditive interaction effects among genes and environment, or between different gene loci, and other complications can be added to equation...
Journal Article
Demography (2006) 43 (4): 587–615.
Published: 01 November 2006
... of these elds, and the journey through them leads to the identi cation of a few regularities that are well-known and others that are less known or less agreed-upon. Very little of it, however, involves or Figure 5. A New Problem: Relations Involved in Selection Social class of origin (genes/environment...
Journal Article
Demography (2010) 47 (Suppl 1): S65–S85.
Published: 01 March 2010
..., including genes, environmental conditions (particularly undernutrition and illness), and gene-environment interactions. Although genes are key determinants of individual height, many studies have suggested that differences in average height across populations are due largely to environmental factors...
Journal Article
Demography (2008) 45 (3): 673–691.
Published: 01 August 2008
... Saludable (Costa Rican Study of Longevity and Healthy Aging; CRELES). Smoking, past and present, is not a factor among males, nor is high blood pressure or elevated cholesterol or triglycerides levels. It does not seem that Costa Ricans have the genes or a diet that reduce these risk factors. The only...
Journal Article
Demography (2010) 47 (1): 45–66.
Published: 01 February 2010
... C.Y. , Rose R.M. , & Cacioppo J.T. ( 2007 ). Social Regulation of Gene Expression in Human Leukocytes . Genome Biology , 8 , R189 – R189 . 10.1186/gb-2007-8-9-r189 Costa D.L. ( 1998 ). The Evolution of Retirement: An American Economic History, 1880–1990 . Chicago...
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