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Gene-environment interaction
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Journal Article
Demography (2014) 51 (1): 119–139.
Published: 27 November 2013
... affected by both environmental and genetic factors (Nelson et al. 2006 ). Emerging evidence from the gene-environment (GxE) interaction literature has made it clear that a full understanding of these complex phenomena requires some information about genetic risks but also a clear accounting of the social...
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in Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index
> Demography
Published: 27 November 2013
Journal Article
Demography (2011) 48 (4): 1517–1533.
Published: 16 August 2011
... et al. 2004 ). However, genetic influences on smoking vary considerably across different social environments (Boardman 2009 ; Boardman et al. 2008 ; Timberlake et al. 2006 ). The environmental moderation of genetic factors is anticipated by the gene-by-environment interaction (GxE) paradigm...
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Journal Article
Demography (2022) 59 (3): 1045–1070.
Published: 01 June 2022
.... They used a genome-wide gene-by-environment interaction approach, which regresses the level of an outcome (in their case, BMI) on each SNP’s interaction with an environmental moderator (in their study, education). They noted the approach’s promise for capturing GxE but also its challenges with statistical...
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Journal Article
Demography (2018) 55 (1): 295–318.
Published: 18 December 2017
... Health , 99 , 480 – 486 . 10.2105/AJPH.2008.134932 . Boardman , J. D. , Domingue , B. W. , Blalock , C. L. , Haberstick , B. C. , Harris , K. M. , & McQueen , M. B. ( 2014 ). Is the gene-environment interaction paradigm relevant to genome-wide studies? The case...
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Journal Article
Demography (2015) 52 (5): 1651–1670.
Published: 29 August 2015
... origins of obesity . Obesity Reviews , 9 , 165 – 180 . 10.1111/j.1467-789X.2007.00392.x . Boardman , J. D. , Domingue , B. W. , Blalock , C. L. , Haberstick , B. C. , Harris , K. M. , & McQueen , M. B. ( 2014 ). Is the gene-environment interaction paradigm relevant...
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Journal Article
Demography (2017) 54 (1): 71–91.
Published: 09 January 2017
... individuals from 6 countries uncovers strong gene-environment interaction for human fertility . Unpublished manuscript. doi: 10.1101/049163 van de Kaa , D. J. ( 1987 ). Europe’s second demographic transition . Population Bulletin , 42 , 1 – 59 . van Doorn , M. , Pop , I...
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Journal Article
Demography (2006) 43 (4): 747–769.
Published: 01 November 2006
... structure, pa- rental education, and neighborhood-level poverty (Billy et al. 1993; Hogan and Kitagawa 1985; Upchurch et al. 1998), are environmental candidates for investigating such gene- environment interactions. SAMPLES Add Health We used data from Add Health, which started as a nationally...
Journal Article
Demography (2001) 38 (4): 563–567.
Published: 01 November 2001
...- monstrable genetic differences consisting of variations in gene frequencies across racial groups (p. 297). Furthermore, the genetic component in their model is immutable in that the environmental and the genetic contributions to determin- ing infant birth weight are not permitted to interact...
Journal Article
Demography (2010) 47 (2): 327–343.
Published: 01 May 2010
... changes in the human gene pool are highly unlikely in one or two generations and have never been observed previ- ously. Thus, if autism is related to genes, it seems axiomatic that the genetic foundation for the increased prevalence of autism rests on a gene-environment interaction involving a change...
Journal Article
Demography (2020) 57 (4): 1513–1541.
Published: 21 July 2020
... be used to back out a rough estimate of broad sense heritability. If we assume that the twin sample is approximately 50% MZ and 50% DZ—and if we invoke the usual assumptions regarding equal environments, minimal gene-environment interactions, and comparable shared environments within pairs—then Falconer’s...
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Journal Article
Demography (2021) 58 (4): 1575–1602.
Published: 01 August 2021
... be a welcome addition to the biodemography literature and would allow the direct prediction of sequence complexity and determine whether genetic components bias the social factors that are included in such prediction models. Ultimately, a PGS will allow for more gene-environment interaction research...
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Journal Article
Demography (2024) 61 (2): 363–392.
Published: 01 April 2024
..., and economics used genetic data to investigate gene–environment interactions ( Boardman et al. 2014 ; Herd et al. 2019 ; Johnson et al. 2022 ; Liu 2018 ; Liu and Guo 2015 ) or to account for genetic confounding ( Fletcher et al. 2021 ; Gaydosh et al. 2018 ). The goal of these studies is to evaluate a role...
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Journal Article
Demography (2010) 47 (1): 1–22.
Published: 01 February 2010
... to test for sexually transmitted infections (STIs) and HIV. To strengthen our genetic design, we collected buccal cell DNA for molecular analysis of genetic and gene-environment interaction effects in health and health behavior. At Wave IV, we focused on the major health risks of the cohort at this time...
Journal Article
Demography (2010) 47 (Suppl 1): S111–S130.
Published: 01 March 2010
..., personality traits result from the interplay of genetic variations with environmental inÀ uences (Loehlin 1992; National Research Council 2006). The gene-environment interaction approach assumes that environmental factors, such as life events, inÀ uence personality, and genes affect individual susceptibility...
Journal Article
Demography (2001) 38 (4): 573–576.
Published: 01 November 2001
... fetal genes could interact with environmental effects; thus we began by testing for main effects. Another reason is that interactions between genotype and environment seem difficult to detect (McCall 1991; Wahlsten 1990): among the possible explanations are methodological limitations that apply to our...
Journal Article
Demography (1997) 34 (1): 17–30.
Published: 01 February 1997
... is that we have not observed extremely long-lived people, say over 130 years old. The as- sumption of a genetically fixed upper bound to life expect- ancy and life span, however, ignores the likelihood of strong gene-environment interactions because these interactions likely had relatively little manifest...
Journal Article
Demography (2013) 50 (4): 1399–1420.
Published: 24 January 2013
... point is the possibility of gene–environment interactions (Neale and Cardon 1992 :22–23). Although we found no evidence that common environmental factors would have a role in terms of having any children, interaction effects between genetic predispositions and features of a social environment...
Journal Article
Demography (2010) 47 (Suppl 1): S65–S85.
Published: 01 March 2010
..., including genes, environmental conditions (particularly undernutrition and illness), and gene-environment interactions. Although genes are key determinants of individual height, many studies have suggested that differences in average height across populations are due largely to environmental factors...
Journal Article
Demography (1990) 27 (2): 185–206.
Published: 01 May 1990
... additively, producing the following phenotype (P) distribution: P=C+PG+E fl.p = L Pr(g)fl.g g a~ = ai + a~ + a;. (5) This model is shown in Figure l(bottom). Terms for nonadditive interaction effects among genes and environment, or between different gene loci, and other complications can be added to equation...
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