Abstract

An unresolved issue in research on child survival is the extent to which familial mortality risk in infancy is due to biological influences net of sociodemographic and economic factors. We examine the effect of consanguinity on early childhood mortality in an Old Order Amish settlement by using the inbreeding coefficient, an explicit measure of the degree of relatedness in one’s ancestry. Inbreeding has a net positive effect on neonatal and postneonatal deaths. We find social, demographic, and population-based sociocultural explanations for this effect among the Amish population, which is known to experience certain genetically transmitted defects associated with mortality.

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References

Al-Awadi, S.A., Naguib, K.K., Moussa, M.A., Farag, T.I., Teebi, A.S., & El-Khalifa, M.Y. (
1986
).
The Effect of Consanguineous Marriages on Reproductive Wastage
.
Clinical Genetics
,
29
,
384
88
. 10.1111/j.1399-0004.1986.tb00509.x
Aldrich, J.H., & Nelson, F.D. (
1984
).
Linear Probability, Logit, and Probit Models
.
Beverly Hills
:
Sage
.
Amish Directory of the Lancaster County Family. 1988. Gordonville, PA: Pequea Publishers.
K. Beiler (
1988
).
Fisher Family History, revised and updated by the Committee of Fisher Descendants
.
Lancaster, PA
:
Eby’s Quality Printing
.
Bitties, A.H. (
1990
).
Consanguineous Marriage: Current Global Incidence and its Relevance to Demographic Research
.
Ann Arbor, MI
:
University of Michigan
.
Bittles, A.H., & Makov, E. (
1988
).
Inbreeding in Human Populations: An Assessment of the Costs
Human Mating Patterns
(pp.
153
67
).
Cambridge
:
Cambridge University Press
.
Bittles, A.H., Shami, S.A., & Rao, N.A. (
1992
).
Consanguineous Marriage in Southern Asia: Incidence, Causes and Effects
. In A.H. Bittles, & D.F. Roberts (Eds.),
Minority Populations: Genetics, Demography and Health
(pp.
102
18
).
London
:
Macmillan Press Ltd
.
Boyce, A.J. (
1988
).
KINSHIP
.
San Antonio, TX
:
Southwest Foundation for Biomedical Research
.
Bundey, S. (
1992
).
A Prospective Study of the Health of Birmingham Babies in Different Ethnic Groups: Interim Findings
. In A.H. Bittles, & D.F. Roberts (Eds.),
Minority Populations: Genetics, Demography and Health
(pp.
143
55
).
London
:
Macmillan Press Ltd
.
Castilla, E.E., & Adams, J. (
1990
).
Migration and Genetic Structure in an Isolated Population in Argentina: Aicuna
. In J. Adams, D.A. Lam, A.I. Hermalin, & P.E. Smouse (Eds.),
Convergent Issues in Genetics and Demography
(pp.
45
62
).
New York
:
Oxford University Press
.
Crow, J.F. (
1986
).
Basic Concepts in Population, Quantitative, and Evolutionary Genetics
.
New York
:
W.H. Freeman Co
.
Curtis, S.L., Diamond, I., & McDonald, J.W. (
1993
).
Birth Interval and Family Effects on Postneonatal Mortality in Brazil
.
Demography
,
30
,
33
43
. 10.2307/2061861
Curtis, S.L. and F. Steele. 1994. “Variations in Familial Neonatal Mortality Risks in Four Countries.” Paper presented at the annual meeting of the Population Association of America, Miami.
Ericksen, J. A., Ericksen, E.P., Hostetler, J.A., & Huntington, G.E. (
1979
).
Fertility Patterns and Trends Among the Old Order Amish
.
Population Studies
,
33
,
255
76
. 10.2307/2173531
Falconer, D.S. (
1989
).
Introduction to Quantitative Genetics
.
Reading, MA
:
Longman Scientific and Technical
.
Freire-Maia, N., & Elisbao, T. (
1984
).
Inbreeding Effect on Morbidity: HI. A Review of the World Literature
.
American Journal of Medical Genetics
,
18
,
391
99
. 10.1002/ajmg.1320180306
Guo, G. (
1993
).
Use of Sibling Data to Estimate Family Mortality Effects in Guatemala
.
Demography
,
30
,
15
32
. 10.2307/2061860
Harper, P., & Roberts, D.F. (
1988
).
Mating Patterns and Genetic Disease
Human Mating Patterns
(pp.
169
81
).
Cambridge
:
Cambridge University Press
.
Hosmer, D.W., & Lemeshow, S. (
1989
).
Applied Logistic Regression
.
New York
:
Wiley & Sons
.
Jakobi, L., & Darlu, P. (
1988
).
Mating Patterns in Isolates
Human Mating Patterns
(pp.
47
59
).
Cambridge
:
Cambridge University Press
.
Jorde, L.B., & Pitkanen, K.J. (
1991
).
Inbreeding in Finland
.
American Journal of Physical Anthropology
,
84
,
127
39
.
Jorde, L.B., Pitkanen, K.J., O’Brien, E., & Eriksson, A.W. (
1992
).
Consanguinity and Genetic Disease in Finland’s Swedish-Speaking Minority
. In A.H. Bittles, & D.F. Roberts (Eds.),
Minority Populations: Genetics, Demography and Health
(pp.
14
34
).
London
:
Macmillan Press Ltd
.
Khoury, M.J., & Cohen, B.H. (
1987
).
Genetic Heterogeneity of Prematurity and Intrauterine Growth Retardation: Clues From the Old Order Amish
.
American Journal of Obstetrics and Gynecology
,
157
,
400
10
.
Khoury, M.J., Cohen, B.H., Diamond, E.L., Chase, G.A., & McKusick, V.A. (
1987
).
Inbreeding and Prereproductive Mortality in the Old Order Amish. I. Genealogie Epidemiology of Inbreeding
.
American Journal of Epidemiology
,
125
,
453
61
.
Khoury, M.J., Cohen, B.H., Diamond, E.L., Chase, G.A., & McKusick, V.A. (
1987
).
Inbreeding and Prereproductive Mortality in the Old Order Amish. III. Direct and Indirect Effects of Inbreeding
.
American Journal of Epidemiology
,
125
,
473
83
.
Khoury, M.J., Cohen, B.H., Newill, C.A., Bias, W., & McKusick, V.A. (
1987
).
Inbreeding and Prereproductive Mortality in the Old Order Amish. II. Genealogie Epidemiology of Prereproductive Mortality
.
American Journal of Epidemiology
,
125
,
462
72
.
Kraybill, D.B. (
1989
).
The Riddle of Amish Culture
.
Baltimore
:
Johns Hopkins University Press
.
The Lancaster County Family Register. 1988. Gordonville, PA: Pequea Publishers.
Lynch, K.A., & Greenhouse, J.B. (
1994
).
Risk Factors for Infant Mortality in Nineteenth-Century Sweden
.
Population Studies
,
48
,
117
33
. 10.1080/0032472031000147506
McDonald, J., & Diamond, I. (
1983
).
Fitting Generalised Linear Models With Linear Inequality Parameter Constraints
.
The GLIM Newsletter
,
8
,
29
36
.
McKusick, V.A., Hostetier, J.A., Egeland, J.A., & Eldridge, R. (
1978
).
The Distribution of Certain Genes in the Old Order Amish
Medical Genetic Studies of the Amish
(pp.
51
67
).
Baltimore
:
Johns Hopkins University Press
.
Miller, J.E. (
1989
).
Is the Relationship Between Birth Intervals and Perinatal Mortality Spurious? Evidence From Hungary and Sweden
.
Population Studies
,
43
,
479
95
. 10.1080/0032472031000144246
Reddy, P.G. (
1987
).
Effects of Consanguineous Marriages on Fertility Among Three Endogamous Groups of Andhra Pradesh
.
Social Biology
,
34
(
1–2
),
68
77
.
Reddy, P.H., & Modell, B. (
1995
).
Consanguinity and Reproductive Behavior in a Tribal Population ‘The Baiga’ in Madhya Pradesh, India
.
Annals of Human Biology
,
22
,
235
46
. 10.1080/03014469500003892
Shami, S.A., Schmitt, L.H., & Bittles, A.H. (
1989
).
Consanguinity Related Prenatal and Postnatal Mortality of the Populations of Seven Pakistani Punjab Cities
.
Journal of Medical Genetics
,
26
,
267
71
. 10.1136/jmg.26.4.267
Thompson, E. (
1990
).
From History to Genes: From Genes to History
. In J. Adams, D.A. Lam, A.I. Hermalin, & P.E. Smouse (Eds.),
Convergent Issues in Genetics and Demography
(pp.
27
43
).
New York
:
Oxford University Press
.
Trussell, J., & Hammerslough, C. (
1983
).
A Hazards-Model Analysis of the Covariates of Infant and Child Mortality in Sri Lanka
.
Demography
,
20
,
1
26
. 10.2307/2060898
Tuncbilek, E., & Koc, I. (
1994
).
Consanguineous Marriage in Turkey and its Impact on Fertility and Mortality
.
Annals of Human Genetics
,
58
,
321
29
. 10.1111/j.1469-1809.1994.tb00729.x
Zenger, E. (
1993
).
Siblings’ Neonatal Mortality Risks and Birth Spacing in Bangladesh
.
Demography
,
30
,
477
88
. 10.2307/2061652