The steady rollout of Covid-19 vaccines comes attached with a series of difficult questions. Are vaccines a human right? Should patents be enforced in a way that puts people in the global South behind in a global queue? These questions are not new; the world struggled with these ethical dilemmas during the HIV-AIDS pandemic at the end of the twentieth century, when global South governments led by Nelson Mandela fought multinational pharmaceutical corporations for the right to essential life-saving drugs. Can the same strategies be mobilized to deal with inequalities in the distribution of the Covid-19 vaccine? This article demonstrates a technological and geopolitical shift in the last two decades that hinder global South solidarities actualized during the HIV-AIDS pandemic. Instead, Banerjee argues that in the present, multinational corporations and Euro-American governments are trying to reverse some of the key political visions and victories of HIV-AIDS internationalism, exploiting the urgency of the Covid-19 crisis to put in place a new vaccine apartheid.