Since independence, African scholars from different traditions (African, Islamic and Western), intellectuals, and politicians have been actively engaging with humanities and social sciences originating from the West and received through the conduit of colonial rule and imperial domination. Both the filiation and the packaging of the knowledge made it suspect and irrelevant to postcolonial societies. But until today the two axiomatic assumptions of knowledge production, policy-oriented/problem-solving research and/or academic research (reduced mainly to humanities), are being resolved at the expense of the latter, circumscribing the territory in which the debate is conducted. It focuses on the possibility (or not) of producing a vernacular conceptual framework, radically detached from the Western colonial social sciences and humanities and its revision by the inclusion of location, race, culture, identities, and alterity. South Africa, which has been inflicted by a vicious racial discrimination and economic exploitation, is leading the discussion, picking up the flag of the decolonization of knowledge.