Anushiravani’s essay is a historical and critical survey of comparative literature in Iran that discusses its present challenges and potentialities for development in the context of new directions in the field. It is divided into three parts; the first examines the origins of comparative literature in Iran. The second deals with the present state of comparative literature programs and journals at Iranian universities and academic centers. This section investigates the main challenges facing this discipline in Iran. The last part speculates on the future trends and directions of comparative literature in Iran in the light of younger scholars’ and graduate students’ interest in interdisciplinary studies, translation, and world literature.