The introduction explores the intersection of race, nature, and logistics in the context of Colombia’s Magdalena River basin. The study spans the colonial period to the present, addressing the social, economic, and ecological transformations shaping the region. It argues that, for centuries, hierarchical relations between different categories of humans have been entangled with hierarchical relations between people and the so-called natural world, and that the Magdalena River has played an important role in that history. It then frames the book’s conceptual problematic: entanglements of race and nature, and their manifestation in an infrastructure megaproject that aims to make the Magdalena River into a logistics corridor. The discussion extends to the river’s centrality to colonial and racial capitalism, examining the links between social inequality and resource extraction. The author also reflects on his own positionality and on the book’s critical, analytical, and stylistic approaches. The introduction ends with a chapter-by-chapter summary.