Informatics of Domination draws on genealogies of domination and diagramming to analyze modes of power—particularly as they manifest through forms of technical systems, networks, and computation. The collection’s title and organizing concept comes from Haraway’s classic essay “A Manifesto for Cyborgs” (1985). While the essay is celebrated for launching the cyborg as a feminist figure imbricated in networks of techno-scientific patriarchy, the manifesto also narrates a wide-ranging shift in the operations of power, marking a move from social relations predominantly structured by industrial capitalism to those structured by information technologies beginning in the second half of the twentieth century—what Haraway terms the informatics of domination. Haraway provides a sweeping two-column chart that diagrams these shifts in power. In attending to the diagrammatic origins of the informatics of domination concept, the book takes Haraway’s chart as an organizing structure and experimental form for examining how informatic technologies extend modes of power in the twenty-first century.