Bodily ways of knowing are introduced as the main theme of this book. The introduction opens with a firsthand observation of an instruction laboratory and a reflection on everyday lab tools and hands-on training in life sciences research. It explores “bodily techniques” and describes the interaction between lab instruments and instrument users as recalibrations and as complex processes of enskillment. A discussion of the Nobel Prize–winning biologists Barbara McClintock and Satoshi Ōmura introduces key concepts explored in this book, that is, the manual; skilled vision; knowledge cultures; and the notion of the (dis)embodied knower that is traced back to Descartes and the seventeenth century's experimental sciences. The introduction concludes with a description of the book's multisited historioethnographic approach, which combines methods from historical epistemology with participatory observations of hands-on experiments.