The spraying of inside walls of houses with insecticides has regained popularity in malaria control. In Ghana it was a corporate social responsibility project of a major gold-mining company that has brought insecticide spraying firmly back as a national agenda. Taking the project of the gold-mining company as a point of departure, this chapter reflects on the relationship between the ecology of spraying, democracy, and para-statal health care. I propose that insecticide spraying in the age of biological resistance is best understood as a real-world experiment. The notion emphasizes the uncertainty and tentativeness that characterizes insecticide spraying against malaria today...