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The introduction frames the book’s main argument: that as ideas shift about what sex is, so do the interventions required to change it and the logic of medical practices intended to do so. The introduction outlines the book’s ethnographic and conceptual support of that argument and details how critical engagements with trans- history, economic shifts in American medicine, and influential ideas in gender theory have informed the project. Trans- therapeutics is offered as a framework for thinking about the assumptions, aims, and ends of trans- medicine, and it is argued that facial feminization is emblematic of a shift away from genital-centric conceptualizations of trans- subjectivity and therefore the kinds of intervention recognized as good trans- medicine.

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