This chapter introduces the challenges protein crystallographers face building models of otherwise imperceptible phenomena. The chapter highlights the ways that protein modelers must cultivate embodied knowledge to visualize, reason through, and articulate their insights into molecular phenomenon. Indeed, modelers must hone their haptic, kinesthetic, and affective dexterities to be able to see, feel, and know the difference between good and bad molecular structures. The chapter describes innovations in ethnographic methods that bring renewed attention to the senses and modes of embodiment in scientific visualization and pedagogy. By foregrounding the performative, gestural, and affectively charged nature of model building, it explores how embodied practices of scientific representation can be better understood in the idiom “rendering.” The chapter also outlines how, by tuning into the affectivity and indeterminacies of scientific inquiry, this book offers a supplement to recent analyses of biocapital and the biopolitical economies of the life sciences.