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This chapter introduces the reader to the techniques involved in interpreting crystallographic data to build molecular models of protein molecules. It argues that molecular model building is a craft practice. It documents the history of molecular model building techniques and materials, detailing the material culture of protein crystallography. This chapter pays close attention to the three-dimensionality of protein models, and to distinct affordances of different modeling media, from physical models made of ready-to-hand materials, to proprietary software designed to enable smooth manipulation of virtual, computer graphic models on-screen. This chapter argues that it is the tangibility and interactivity of these...

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