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Postgenomics cannot be adequately conceptualized as a simple “break” or “transition” from one era to the next. Nor can it be characterized as a straightforward continuation of genetics or genomics. Rather, the essays in this volume collectively begin to theorize postgenomics in terms of an ongoing struggle to find new ways of thinking, working, and explaining within the parameters set by the tools of genomics. Postgenomics emerges from a tension between the constraints of specific tools and methods and biologists’ attempts to draw new sorts of models and findings from them. This concluding essay examines how these tensions play out in the domains of scientific explanation, knowledge authorization, and the translation of basic biology to medical applications.

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