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During the postgenomic era, genomes have become a shared platform for biological research across many fields. Postgenomics is reshaping debates over genetic determinism, reductionism, the role of the social and the environmental in human health and disease, and even the notion of the genome itself. This introductory essay argues that humanities and social science analysis can help explore the uncertain, transitional, and contested terrain of postgenomics, offering critical examination of the continuities and ruptures instituted by the spread of genomic data and technologies throughout the life sciences over the past decade. Science studies scholars examining the life sciences, in turn, must reimagine their role and refresh their theoretical toolkit in the postgenomic age.

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